Alice Chen Selected Research

EZN 2968

2/2014

Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors.

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Alice Chen Research Topics

Disease

47	Neoplasms (Cancer) 03/2024 - 09/2007
6	Lymphoma (Lymphomas) 08/2017 - 05/2011
5	Fatigue 01/2020 - 12/2003
5	Disease Progression 01/2019 - 07/2011
4	Hypertension (High Blood Pressure) 11/2020 - 10/2011
4	Breast Neoplasms (Breast Cancer) 01/2020 - 06/2012
4	Hypoxia (Hypoxemia) 01/2019 - 02/2014
4	Glioma (Gliomas) 01/2017 - 07/2011
4	Circulating Neoplastic Cells 07/2016 - 09/2011
4	Ovarian Neoplasms (Ovarian Cancer) 11/2015 - 03/2012
3	Melanoma (Melanoma, Malignant) 04/2024 - 10/2011
3	Neutropenia 01/2023 - 12/2003
3	Triple Negative Breast Neoplasms 01/2022 - 07/2011
3	Multiple Sclerosis 01/2020 - 11/2006
3	Fanconi Anemia (Fanconi's Anemia) 01/2020 - 07/2016
3	Diarrhea 01/2020 - 12/2003
3	Prostatic Neoplasms (Prostate Cancer) 11/2018 - 12/2011
3	Thrombocytopenia (Thrombopenia) 10/2018 - 12/2003
3	Brain Neoplasms (Brain Tumor) 01/2017 - 07/2011
3	Glioblastoma (Glioblastoma Multiforme) 06/2013 - 07/2011
2	Infections 01/2023 - 05/2013
2	Fallopian Tube Neoplasms 01/2020 - 01/2017
2	Body Weight (Weight, Body) 01/2019 - 05/2013
2	Colorectal Neoplasms (Colorectal Cancer) 01/2019 - 11/2012
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019 - 02/2017
2	Mucositis 01/2019 - 02/2017
2	Sickle Cell Anemia (Hemoglobin S Disease) 12/2018 - 11/2014
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 10/2018 - 12/2014
2	Pain (Aches) 04/2018 - 07/2005
2	Nausea 08/2017 - 02/2014
2	Leukemia 02/2017 - 05/2010
2	Peritoneal Neoplasms 01/2017 - 01/2015
2	Neoplasm Metastasis (Metastasis) 04/2012 - 12/2011
1	Liver Diseases (Liver Disease) 03/2024
1	Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral) 03/2024
1	Stroke (Strokes) 10/2023
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/2023
1	COVID-19 01/2021
1	Ovarian Epithelial Carcinoma 01/2021
1	Pre-Eclampsia (Preeclampsia) 11/2020
1	Fever (Fevers) 11/2020
1	Eclampsia 11/2020
1	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 05/2020
1	Myocarditis (Carditis) 03/2020

Drug/Important Bio-Agent (IBA)

23	veliparibIBA 01/2022 - 06/2009
18	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2022 - 06/2009
8	afliberceptIBA 11/2018 - 07/2011
7	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2022 - 06/2009
6	Biomarkers (Surrogate Marker)IBA 01/2020 - 12/2007
6	Temozolomide (Temodar)FDA LinkGeneric 01/2019 - 07/2011
5	Proteins (Proteins, Gene)FDA Link 10/2020 - 07/2011
4	Bevacizumab (Avastin)FDA Link 01/2021 - 05/2011
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 05/2011
4	Poly Adenosine Diphosphate RiboseIBA 06/2012 - 06/2009
3	CytokinesIBA 01/2023 - 06/2013
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2022 - 03/2012
3	Alkylating AgentsIBA 01/2022 - 03/2012
3	DNA (Deoxyribonucleic Acid)IBA 10/2020 - 06/2012
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 11/2018 - 07/2011
3	Topotecan (Hycamtin)FDA LinkGeneric 01/2018 - 09/2011
2	Immune Checkpoint InhibitorsIBA 12/2023 - 01/2023
2	Vorinostat FDA Link 08/2023 - 05/2017
2	NSC 724998IBA 01/2023 - 07/2016
2	PlatinumIBA 01/2022 - 01/2020
2	RNA (Ribonucleic Acid)IBA 01/2021 - 05/2013
2	Hormones (Hormone)IBA 01/2020 - 01/2013
2	Carboplatin (JM8)FDA LinkGeneric 01/2020 - 02/2017
2	AndrogensIBA 01/2019 - 11/2018
2	Angiogenesis InhibitorsIBA 01/2019 - 10/2011
2	IsoantibodiesIBA 12/2018 - 11/2014
2	Gemcitabine FDA Link 09/2017 - 12/2003
2	Histones (Histone)IBA 02/2017 - 07/2016
2	ErbB Receptors (EGF Receptor)IBA 01/2014 - 04/2010
2	IntegrinsIBA 04/2012 - 12/2011
2	CilengitideIBA 04/2012 - 12/2011
2	Phosphatidylcholines (Phosphatidylcholine)IBA 07/2004 - 09/2003
1	Eosine Yellowish-(YS) (Eosin)IBA 04/2024
1	Hematoxylin (Haematoxylon)IBA 04/2024
1	belinostatIBA 03/2024
1	salicylhydroxamic acid (SHAM)IBA 10/2023
1	Cathepsin BIBA 10/2023
1	Topoisomerase InhibitorsIBA 01/2022
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022
1	Viral RNAIBA 01/2021
1	MutL Protein Homolog 1IBA 10/2020
1	TensinsIBA 10/2020
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2020
1	Co-Repressor ProteinsIBA 10/2020
1	MutS ProteinsIBA 10/2020
1	Vitamin D FDA LinkGeneric 05/2020
1	Transaminases (Aminotransferases)IBA 01/2020

Therapy/Procedure

18	Therapeutics 08/2023 - 06/2009
10	Drug Therapy (Chemotherapy) 01/2021 - 07/2011
5	Radiotherapy 01/2019 - 02/2014
2	Castration 04/2012 - 12/2011
2	Oral Administration 03/2012 - 07/2005
1	Mechanical Ventilators (Ventilator) 01/2023
1	Prenatal Care (Care, Prenatal) 11/2020
1	Maze Procedure 03/2020
1	Self-Help Devices (Assistive Technology) 01/2020